解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:To date, human peripheral blood mononuclear cells (PBMCs) have been used mainly in immune stimulation assays and the interpretation of data can be influenced by the previous immunological history of donors and cross reactivity with other infectious agents. Resolving these limitations requires an alternative ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1781-4
更新日期:2017-03-27 00:00:00
abstract:BACKGROUND:Heads of Government from Asia and the Pacific have committed to a malaria-free region by 2030. In 2015, the total number of confirmed cases reported to the World Health Organization by 22 Asia Pacific countries was 2,461,025. However, this was likely a gross underestimate due in part to incidence data not be...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1774-3
更新日期:2017-03-21 00:00:00
abstract:BACKGROUND:Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a deletion of the hrp2 gene yield false-negative RDTs and there are concerns the sensitivity of HRP2-ba...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1768-1
更新日期:2017-03-20 00:00:00
abstract:BACKGROUND:Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission. However, PQ metabolites cause haemolysis in patients deficient in the enzyme glucose-6-phosphate dehydrogenase (G6PD). Fifteen PQ-thiazolidinone derivatives, synthesized through one-post reactions from primaqui...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1755-6
更新日期:2017-03-09 00:00:00
abstract:BACKGROUND:Anti-malarial herbal preparations (HPs) continue to enjoy high patronage in Ghana despite reports that the artemisinin-based combination therapy (ACT), the recommended first choice for treatment of uncomplicated malaria in the country, remains efficacious. A major issue with the use of these preparations is ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1757-4
更新日期:2017-03-04 00:00:00
abstract:BACKGROUND:Malaria rapid diagnostic tests (RDTs) enable point-of-care testing to be nearly as sensitive and specific as reference microscopy. The Senegal National Malaria Control Programme introduced RDTs in 2007, along with a case management algorithm for uncomplicated febrile illness, in which the first step stipulat...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1750-y
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Insecticide-treated clothing (ITC) has long been used for military and outdoor recreational purposes and there is substantial evidence to show that it can protect against arthropod biting. As a complementary vector control measure, ITC could be used to address outdoor transmission of malaria, particularly am...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-017-1737-8
更新日期:2017-02-28 00:00:00
abstract:BACKGROUND:A key component of malaria elimination campaigns is the identification and targeting of high risk populations. To characterize high risk populations in north central Namibia, a prospective health facility-based case-control study was conducted from December 2012-July 2014. Cases (n = 107) were all patients p...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1719-x
更新日期:2017-02-10 00:00:00
abstract:BACKGROUND:Malaria is a notifiable disease in the Netherlands, a non-endemic country. Imported malaria infections occur regularly among travellers, migrants and visitors. Surveillance data were analysed from 2008 to 2015. Trends in amounts of notifications among risk groups were analysed using Poisson regression. For a...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1711-5
更新日期:2017-02-02 00:00:00
abstract:BACKGROUND:Diagnosis of Plasmodium falciparum is often based on detection of histidine-rich protein 2 (HRP2) in blood. Most HRP2-based assays have high sensitivity and specificity; however, authors have suggested that antibodies (Ab) to HRP2 could reduce assay sensitivity. This study sought to characterize the antibody...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1704-4
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:When discussing the relationship between meteorological factors and malaria, previous studies mainly focus on the interaction between different climatic factors, while the possible interaction within one particular climatic predictor at different lag periods has been largely neglected. In this study, this is...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1706-2
更新日期:2017-01-31 00:00:00
abstract:BACKGROUND:Shandong Province experienced a declining malaria trend of local-acquired transmission, but the increasing imported malaria remains a challenge. Therefore, understanding the epidemiological characteristics of malaria and the control and elimination strategy and interventions is needed for better planning to ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1708-0
更新日期:2017-01-31 00:00:00
abstract:BACKGROUND:The impact of sulfadoxine-pyrimethamine (SP) used as intermittent preventive treatment during pregnancy (IPTp-SP) on mutant parasite selection has been poorly documented in Burkina Faso. This study sought first to explore the relationship between IPTp-SP and the presence of mutant parasites. Second, to asses...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1695-1
更新日期:2017-01-23 00:00:00
abstract:BACKGROUND:In recent years, malaria (Plasmodium vivax and Plasmodium falciparum) has been successfully controlled in the Ecuador-Peru coastal border region. The aim of this study was to document this control effort and to identify the best practices and lessons learned that are applicable to malaria control and to othe...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1630-x
更新日期:2016-11-28 00:00:00
abstract:BACKGROUND:Subsistence rice farmers in south-eastern Tanzania are often migratory, spending weeks or months tending to crops in distant fields along the river valleys and living in improvised structures known as Shamba huts, not fully protected from mosquitoes. These farmers also experience poor access to organized pre...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1616-8
更新日期:2016-11-22 00:00:00
abstract:BACKGROUND:Malaria antibody responses measured at delivery have been associated with protection from maternal anaemia and low birth weight deliveries. Whether malarial antibodies present in the first half of pregnancy may protect from these or other poor birth outcomes is unclear. To determine whether malaria antibodie...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1597-7
更新日期:2016-11-09 00:00:00
abstract:BACKGROUND:Cases of transfusion-transmitted malaria have been described around the world and highlighted in some studies. Semi-immune individuals are more likely to transmit malaria as they may be asymptomatic. Some countries allow blood donations only based on epidemiological criteria while others reinforce their crit...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1586-x
更新日期:2016-11-09 00:00:00
abstract:BACKGROUND:Insecticide-treated bed nets (ITN) have been shown to be efficacious in reducing malaria morbidity and mortality in many regions. Unfortunately in some areas, malaria has persisted despite the scale up of ITNs. Recent reports indicate that human behaviour and mosquito behaviour are potential threats to the e...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1575-0
更新日期:2016-11-08 00:00:00
abstract:BACKGROUND:Over the past several years, thousands of microRNAs (miRNAs) have been identified in the genomes of various insects through cloning and sequencing or even by computational prediction. However, the number of miRNAs identified in anopheline species is low and little is known about their role. The mosquito Anop...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1591-0
更新日期:2016-11-08 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12936-016-1486-0.]. ...
journal_title:Malaria journal
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12936-016-1544-7
更新日期:2016-09-27 00:00:00
abstract:BACKGROUND:A malaria eradication goal has been proposed, at the same time as a new global strategy and implementation framework. Countries are considering the strategies and tools that will enable progress towards malaria goals. The eliminating malaria case-study series reports were reviewed to identify successful prog...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1518-9
更新日期:2016-09-22 00:00:00
abstract:BACKGROUND:Internally displaced persons (IDP) represent vulnerable populations whose public health conditions merit special attention. In the China-Myanmar border area, human movement and resettlements of IDP can influence malaria transmission. Comparison of disease incidence and vector densities between IDP camps and ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1512-2
更新日期:2016-09-15 00:00:00
abstract:BACKGROUND:As malaria transmission declines, it becomes more geographically focused and more likely due to asymptomatic and non-falciparum infections. To inform malaria elimination planning in the context of this changing epidemiology, local assessments on the risk factors for malaria infection are necessary, yet chall...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1523-z
更新日期:2016-09-13 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) is a frequently encountered complication of imported Plasmodium falciparum infection. Markers of structural kidney damage have been found to detect AKI earlier than serum creatinine-based prediction models but have not yet been evaluated in imported malaria. This pilot study aims to...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1516-y
更新日期:2016-09-09 00:00:00
abstract:BACKGROUND:Sub-Saharan Africa (SSA) has embarked on a new era of dam building to improve food security and promote economic development. Nonetheless, the future impacts of dams on malaria transmission are poorly understood and seldom investigated in the context of climate and demographic change. METHODS:The distributi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1498-9
更新日期:2016-09-05 00:00:00
abstract:BACKGROUND:After the decrease in clinical malaria incidence observed in Mozambique until 2009, a steady resurgence of cases per year has been reported nationally, reaching alarming levels in 2014. However, little is known about the clinical profile of the cases presented, or the possible epidemiological factors contrib...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1496-y
更新日期:2016-08-31 00:00:00
abstract:BACKGROUND:Mass distribution campaigns of insecticide-treated nets for malaria prevention are usually accompanied by intensive behaviour change communication (BCC) to encourage hanging and use of nets. However, data on the effectiveness of these communication efforts are scarce. In preparation for the next round of mas...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1463-7
更新日期:2016-08-19 00:00:00
abstract::The substantial impact of cross-border collaborative control efforts on the burden of malaria in southern Africa has previously been demonstrated through the successes of the Lubombo Spatial Development Initiative. Increases in malaria cases recorded in the three partner countries (Mozambique, South Africa, Swaziland)...
journal_title:Malaria journal
pub_type: 社论
doi:10.1186/s12936-016-1470-8
更新日期:2016-08-18 00:00:00
abstract:BACKGROUND:Anti-malarial drugs are the major focus in the prevention and treatment of malaria. Artemisinin-based combination therapy (ACT) is the WHO recommended first-line treatment for Plasmodium falciparum malaria across the endemic world. Also ACT is increasingly relied upon in treating Plasmodium vivax malaria whe...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1443-y
更新日期:2016-07-22 00:00:00
abstract:BACKGROUND:Anopheles arabiensis is a dominant vector of malaria in sub-Saharan Africa, which feeds indoors and outdoors on human and other vertebrate hosts, making it a difficult species to control with existing control methods. Novel methods that reduce human-vector interactions are, therefore, required to improve the...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1386-3
更新日期:2016-07-21 00:00:00
abstract:BACKGROUND:In Ghana, malaria is endemic and perennial (with significant seasonal variations in the three Northern Regions), accounting for 33 % of all deaths among children under 5 years old, with prevalence rates in children under-five ranging from 11 % in Greater Accra to 40 % in Northern Region. Ghana adopted the WH...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1418-z
更新日期:2016-07-16 00:00:00
abstract:BACKGROUND:Malaria is one of the most severe global public health problems worldwide, particularly in Africa, where Nigeria has the greatest number of malaria cases. This community-based study was designed to investigate the prevalence and risk factors of malaria and to evaluate the knowledge, attitudes, and practices ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1394-3
更新日期:2016-07-08 00:00:00
abstract:BACKGROUND:Artemisinin-based combination therapy (ACT) has been adopted by the World Health Organization as a first-line treatment for uncomplicated Plasmodium falciparum malaria. In endemic regions, it has proven more effective in treating the disease, and even in reducing its transmission. Nonetheless, there is a sca...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1408-1
更新日期:2016-07-02 00:00:00
abstract:BACKGROUND:In areas with ongoing malaria transmission, strategies to clear parasites from populations can reduce infection and transmission. The objective of this paper was to describe a malaria mass testing and treatment (MTAT) intervention implemented in six kebeles (villages) in Amhara Region, Ethiopia, at the begin...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1333-3
更新日期:2016-06-02 00:00:00
abstract:BACKGROUND:The objective of this study to detect Plasmodium and a subspecies of Plasmodium using filter paper in malaria endemic province, Sanliurfa, in Turkey, compare the results of nested PCR (nPCR) with microscopy for the diagnosis of malaria and present the epidemiological data of malaria. METHODS:This study was ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1334-2
更新日期:2016-05-28 00:00:00
abstract:BACKGROUND:Glucose 6-phosphate dehydrogenase (G6PD) is an enzyme involved in prevention of cellular oxidative damage, particularly protecting erythrocytes from haemolysis. An estimated 400 million people present variable degrees of inherited G6PD deficiency (G6PDd) which puts them at risk for developing haemolysis trig...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1343-1
更新日期:2016-05-26 00:00:00
abstract:BACKGROUND:Several public health interventions to improve management of patients with fever are largely focused on the public sector yet a high proportion of patients seek care outside the formal healthcare sector. Few studies have provided information on the determinants of utilization of the private sector as against...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1351-1
更新日期:2016-05-25 00:00:00
abstract:BACKGROUND:Numerous countries around the world are approaching malaria elimination. Until global eradication is achieved, countries that successfully eliminate the disease will contend with parasite reintroduction through international movement of infected people. Human-mediated parasite mobility is also important with...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1315-5
更新日期:2016-05-11 00:00:00
abstract:BACKGROUND:Plasmodium falciparum merozoite antigens elicit antibody responses in malaria-endemic populations, some of which are clinically protective, which is one of the reasons why merozoite antigens are the focus of malaria vaccine development efforts. Polymorphisms in several merozoite antigen-encoding genes are th...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-016-1304-8
更新日期:2016-05-06 00:00:00
abstract:BACKGROUND:The potential emergence and spread of resistance to artemisinins in the Plasmodium falciparum malaria parasite constitutes a major global health threat. Hence, improving the efficacy of artemisinins and of artemisinin-based combination therapy (ACT) represents a major short-term goal in the global fight agai...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1317-3
更新日期:2016-05-06 00:00:00